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Secretory VSMC-derived THBS1 promotes macrophage M1 polarization and inflammation in intracranial aneurysms via the CD47/NF-κB axis

BackgroundChronic vascular inflammation and immune cell infiltration are key pathogenic features of intracranial aneurysms (IAs). Although phenotypic switching of vascular smooth muscle cells (VSMCs) and macrophage M1 polarization have both been observed in IAs, the intercellular communication mecha...

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Autori principali: Jianhuang Huang, Qixiu Wang, Yangyang Lin, Jianning Chen, Caihou Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-04-01
Serie:Frontiers in Immunology
Soggetti:
CD47
intercellular communication
intracranial aneurysm
M1 macrophage
thrombospondin-1
VSMC phenotypic switching
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1790488/full
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