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Multi-scale characterisation of homologous recombination deficiency in breast cancer

Abstract Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using ‘mutational signatures’. However, these patterns...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2023-11-01
Rangatū:Genome Medicine
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s13073-023-01239-7
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