Multi-scale characterisation of homologous recombination deficiency in breast cancer
Abstract Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using ‘mutational signatures’. However, these patterns...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BMC
2023-11-01
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| Reeks: | Genome Medicine |
| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1186/s13073-023-01239-7 |
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