Synthesis of some novel coumarin-based heterocycles, elucidation of their antifungal behavior, molecular docking and computational studies

Abstract A novel series of coumarin–cyanoacetohydrazide hybrids was synthesized via efficient strategies that exploit the nucleophilic and electrophilic functionalities of the cyanoacetohydrazide scaffold. The designed framework incorporated a C-4 amino-substituted coumarin nucleus, enabling the con...

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Hauptverfasser:	Mahmoud F. Ismail, Mounir A. I. Salem, Magda I. Marzouk, Naglaa F. H. Mahmoud, Nashwa H. Abdullah, Mustafa A. S. Gouda
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-04-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Cyanoacetohydrazide Coumarin Fused coumarin Antifungal activity Computational study
Online-Zugang:	https://doi.org/10.1038/s41598-026-43854-5
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