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Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vert...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Sash Lopaticki, Annie S. P. Yang, Alan John, Nichollas E. Scott, James P. Lingford, Matthew T. O’Neill, Sara M. Erickson, Nicole C. McKenzie, Charlie Jennison, Lachlan W. Whitehead, Donna N. Douglas, Norman M. Kneteman, Ethan D. Goddard-Borger, Justin A. Boddey
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Nature Portfolio 2017-09-01
Цуврал:Nature Communications
Онлайн хандалт:https://doi.org/10.1038/s41467-017-00571-y
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