Proliferative activity of antigen-specific CD154+ T cells against bacterial and fungal respiratory pathogens in cystic fibrosis decreases after initiation of highly effective CFTR modulator therapy

Background: Together with impaired mucociliary clearance, lung disease in cystic fibrosis (CF) is driven by dysregulation of innate and adaptive immunity caused by dysfunctional CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), leading to airway infection and hyperinflamma-tion. The highly...

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Principais autores:	Patience N. Eschenhagen, Petra Bacher, Claudia Grehn, Jochen G. Mainz, Alexander Scheffold, Carsten Schwarz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	cystic fibrosis antigen-specific T cells Ki-67 Pseudomonas aeruginosa Aspergillus fumigatus total IgE
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1180826/full
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