Proliferative activity of antigen-specific CD154+ T cells against bacterial and fungal respiratory pathogens in cystic fibrosis decreases after initiation of highly effective CFTR modulator therapy

Background: Together with impaired mucociliary clearance, lung disease in cystic fibrosis (CF) is driven by dysregulation of innate and adaptive immunity caused by dysfunctional CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), leading to airway infection and hyperinflamma-tion. The highly...

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Bibliographic Details

Main Authors:	Patience N. Eschenhagen, Petra Bacher, Claudia Grehn, Jochen G. Mainz, Alexander Scheffold, Carsten Schwarz
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Pharmacology
Subjects:	cystic fibrosis antigen-specific T cells Ki-67 Pseudomonas aeruginosa Aspergillus fumigatus total IgE
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1180826/full
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