Differential modulation of cancer‐related genes by mitochondrial DNA haplogroups and the STING DNA sensing system

Abstract Activation of the Simulator of Interferon Genes (STING) system by mitochondrial (mt) DNA can upregulate type 1 interferon genes and enhance immune responses to combat bacterial and viral infections. In cancers, the tumor‐derived DNA activates STING leading to upregulation of IFN‐beta and in...

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Detalhes bibliográficos

Principais autores:	Kevin Schneider, Marilyn Chwa, Shari R. Atilano, Sonali Nashine, Nitin Udar, David S. Boyer, S. Michal Jazwinski, Michael V. Miceli, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2022-10-01
coleção:	FASEB BioAdvances
Assuntos:	cancer genes mitochondrial DNA haplogroups simulator of interferon genes (STING)
Acesso em linha:	https://doi.org/10.1096/fba.2019-00044
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