European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects

Background: Cisplatin, a powerful antitumor agent, causes formation of DNA adducts, and activation of apoptotic pathways. Presently, cisplatin resistance develops in up to 70% of patients but the underlying molecular mechanism(s) are unclear and there are no markers to determine which patients will...

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Detalhes bibliográficos

Principais autores:	Tej H. Patel, Lucas Norman, Steven Chang, Sina Abedi, Catherine Liu, Marilyn Chwa, Shari R. Atilano, Kunal Thaker, Stephanie Lu, S. Michal Jazwinski, Michael V. Miceli, Nitin Udar, Daniela Bota, M. Cristina Kenney
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-07-01
coleção:	Frontiers in Oncology
Assuntos:	cisplatin mitochondria cybrids drug resistance mtDNA haplogroups
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fonc.2019.00640/full
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