Analysis of Cytosine Base Editors in Bovine Zygotes: Efficiency and Editing Window Characterization Through Targeting the <i>MYO7A</i> Gene

Cytosine base editors (CBEs) enable precise C-to-T (G-to-A) conversions in genomic DNA, offering significant potential for specific gene editing. This study compared the prototypical Base Editor 3 (BE3) and a modified variant, BE3-Y130F, which utilizes an hA3A deaminase with the Y130F mutation, focu...

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Detalhes bibliográficos

Principais autores:	Junghyun Ryu, Rebecca Tippner-Hedges, Martha Neuringer, Jon D. Hennebold
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-12-01
coleção:	Current Issues in Molecular Biology
Assuntos:	cytosine base editing gene editing Usher syndrome
Acesso em linha:	https://www.mdpi.com/1467-3045/47/12/1033
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