Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the <i>Huntingtin</i> Gene

Huntington’s disease (HD) arises from expanded CAG repeats in exon 1 of the <i>Huntingtin</i> (<i>HTT</i>) gene. The resultant misfolded HTT protein accumulates within neuronal cells, negatively impacting their function and survival. Ultimately, HTT accumulation results in cell death, causing the de...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Junghyun Ryu, John P. Statz, William Chan, Kiana Oyama, Maggie Custer, Martin Wienisch, Richard Chen, Carol B. Hanna, Jon D. Hennebold
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	MDPI AG 2024-05-01
श्रृंखला:	Cells
विषय:	Huntington’s disease rhesus macaque CRISPR germline editing
ऑनलाइन पहुंच:	https://www.mdpi.com/2073-4409/13/10/829
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