Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium

Introduction: Epidemiological studies have implicated ovulation as a risk factor for ovarian high-grade serous carcinoma (HGSC) at the initiation stage. Precancerous lesions of HGSC commonly exhibit TP53 mutations attributed to DNA deamination and are frequently localized in the fallopian tube epith...

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Auteurs principaux:	Kanchana Subramani, Hsuan-Shun Huang, Pao-Chu Chen, Dah-Ching Ding, Tang-Yuan Chu
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-01-01
Collection:	Neoplasia: An International Journal for Oncology Research
Sujets:	Fallopian tube fimbria Follicular fluid Reactive oxygen species TP53 mutation Activation-induced cytidine deaminase Mutagenesis
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S147655862400126X
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