Neurodegenerative NMNAT2 Deficiency Promotes APP Processing in a SARM1-Dependent Manner
Metabolic dysfunction and proteinopathy are hallmarks of neurodegenerative disease, yet their mechanistic interplay remains poorly understood. Here, we show that loss of the neuronal NAD<sup>+</sup>-synthesizing enzyme Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) disrupts amyloid precu...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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MDPI AG
2026-06-01
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| Schriftenreihe: | Cells |
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| Online-Zugang: | https://www.mdpi.com/2073-4409/15/12/1100 |
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