Novel insights into histone lysine methyltransferases in cancer therapy: From epigenetic regulation to selective drugs

The reversible and precise temporal and spatial regulation of histone lysine methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of KMTs is associated with tumor initiation, metastasis, chemoresistance, invasiveness, and the immune microenvironment. Therapeutically, t...

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Autores principales: Qili Liao, Jie Yang, Shengfang Ge, Peiwei Chai, Jiayan Fan, Renbing Jia
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2023-02-01
Colección:Journal of Pharmaceutical Analysis
Materias:
Cancer
Epigenetics
Histone lysine methyltransferase
Epigenetic inhibitors
Combined therapeutic strategy
Clinical application
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2095177922001228
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