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LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion

Monocyte adhesion is a crucial step in transmigration and can be induced by lipopolysaccharide (LPS). Here, we studied the role of mammalian target of rapamycin (mTOR) complexes, mTORC1 and mTORC2, and PKC in this process. We used THP-1 cells, a human monocytic cell line, to investigate monocyte adh...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Marcelle C. Ribeiro, Diogo B. Peruchetti, Leandro S. Silva, João L. Silva-Filho, Mariana C. Souza, Maria das Graças Henriques, Celso Caruso-Neves, Ana Acacia S. Pinheiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-07-01
Schriftenreihe:Frontiers in Molecular Biosciences
Schlagworte:
lipopolysaccharide
mTORC1
mTORC2
protein kinase C
phorbol ester
human acute monocytic leukemia cell line
Online-Zugang:https://www.frontiersin.org/article/10.3389/fmolb.2018.00067/full
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