Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma treatment resistance in females

Abstract Background Glioblastoma or GBM (IDH wild-type) is an aggressive brain tumor that is notoriously resistant to treatment, with an average survival time of 17 months. While the overall outcome is poor for both males and females, sex differences in GBM incidence and outcome suggest sex-specific...

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Detalhes bibliográficos

Principais autores:	Tomisin Adebari, Viola Fanfani, Marouen Ben Guebila, Derrick DeConti, Katherine Hoff Shutta, Camila M. Lopes-Ramos, Lauren Hsu, Dawn L. DeMeo, John Quackenbush, Tara Eicher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Biology of Sex Differences
Assuntos:	Glioblastoma Low-grade glioma Gene regulatory network Transcription factor Gene expression Hypoxia
Acesso em linha:	https://doi.org/10.1186/s13293-026-00927-4
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