Metabolic Interactions of Side-chain Extended and Unsaturated Vitamin D Analogs with Cytochrome P450 Enzymes: Integrating Theoretical and Experimental Approaches

The clinical use of 1,25-dihydroxycholecalciferol (1,25D3), the active form of vitamin D₃, is limited by its calcemic side effects and rapid metabolic degradation. To overcome these limitations, we designed novel vitamin D analogs with extended, rigidified, and branched side chains. Among...

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Autori principali:	Teresa Żołek, Mayur Kadam, Sharmin Nadkarni, Kaori Yasuda, Michał Chodyński, Krzysztof Krajewski, Olga Michalak, Joanna Tobiasz, Marek Kubiszewski, Toshiyuki Sakaki, Andrzej Kutner
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-08-01
Serie:	Biomolecules
Soggetti:	vitamin D analog cytochrome CYP3A4 cytochrome CYP24A1 computational modeling <b>PRI-1906</b> <b>PRI-1927</b>
Accesso online:	https://www.mdpi.com/2218-273X/15/9/1222
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