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In vitro inhibition of mouse liver microsomal cytochrome P450 (CYP) subfamilies by the diterpenes synagrantol A and G isolated from the latex of Euphorbia umbellata

Abstract Phorbol esters are diterpenoids found in the genus Euphorbia (Euphorbiaceae). Synagrantol A (Phorbol-3,4,12,13-tetraacetate-20-phenylacetate) and G (20-deoxyphorbol-3,4,12-triacetate-13-phenylacetate) are phorbol esters from Euphorbia umbellata latex that are under investigation for their a...

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Main Authors: Thaís de Sousa Rolim, João Batista de Freitas Tostes, Carlos Henrique Ramos, Ana Cecilia Amado Xavier de Oliveira, Francisco José Roma Paumgartten, Davyson Moreira Lima, Antonio Carlos Siani
Format: Artigo
Language:Inglês
Published: Instituto de Pesquisas Jardim Botânico do Rio de Janeiro 2025-11-01
Series:Rodriguésia
Subjects:
CYP1A, CYP2A, CYP2B and CYP3A enzyme isoforms
Euphorbia umbellata
phorbol esters
synagrantol A
synagrantol G
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602025000102006&tlng=en
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