Isothermal and protein-free cascade catalytic hairpin assembly induced-DNAzyme sensing strategy for sensitive miRNA analysis

Abstract Sequence-specific microRNAs (miRNAs) represent promising biomarkers for tumor diagnosis, while current detection methods are often limited by stringent temperature requirements and excessive protease dependency. Herein, we present an isothermal, protein-free cascaded amplification circuit f...

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Principais autores:	Yuepeng Zhang, Yuhua Sun, Xueshan Gong, Shuang Zhao, Weiwei Cao, Hongbo Wang, Hao Wang, Xi Zhang, Changwei Du, Zhiguo Chen, Lu Deng
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2025-12-01
叢編:	Scientific Reports
主題:	Catalytic hairpin assembly DNAzyme MiRNA analysis Fluorescence
在線閱讀:	https://doi.org/10.1038/s41598-025-27979-7
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