Isothermal and protein-free cascade catalytic hairpin assembly induced-DNAzyme sensing strategy for sensitive miRNA analysis

Abstract Sequence-specific microRNAs (miRNAs) represent promising biomarkers for tumor diagnosis, while current detection methods are often limited by stringent temperature requirements and excessive protease dependency. Herein, we present an isothermal, protein-free cascaded amplification circuit f...

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Библиографические подробности

Главные авторы:	Yuepeng Zhang, Yuhua Sun, Xueshan Gong, Shuang Zhao, Weiwei Cao, Hongbo Wang, Hao Wang, Xi Zhang, Changwei Du, Zhiguo Chen, Lu Deng
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2025-12-01
Серии:	Scientific Reports
Предметы:	Catalytic hairpin assembly DNAzyme MiRNA analysis Fluorescence
Online-ссылка:	https://doi.org/10.1038/s41598-025-27979-7
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