Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss

Chromosomal abnormalities involving telomeric associations (TAs) often precede replicative senescence and abnormal chromosome configurations. We report here that telomere cleavage following exposure to proapoptotic agents is an early event in apoptosis. Exposure of human and murine cancer cells to a...

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Bibliografiske detaljer

Principais autores:	Asha S. Multani, Mustafa Ozen, Satya Narayad, Virendra Kumar, Joya Chandra, David J. McConkey, Robert A. Newman, Sen Pathak
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2000-07-01
Serier:	Neoplasia: An International Journal for Oncology Research
Fag:	telomeric erosion DNA fragmentation caspase inhibitors fluorescence in situ hybridization telomeric-repeat binding factor (TRF)
Online adgang:	http://www.sciencedirect.com/science/article/pii/S1476558600800068
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