Development of a DNA double-strand break-free base editing tool in Corynebacterium glutamicum for genome editing and metabolic engineering

As a traditional amino acid producing bacterium, Corynebacterium glutamicum is a platform strain for production of various fine chemicals. Based on the CRISPR (Clustered regularly interspaced short palindromic repeats)-Cas9 system, gene editing tools that enable base conversion in the genome of C. g...

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Principais autores:	Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Long Liu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2020-12-01
Series:	Metabolic Engineering Communications
Assuntos:	Base editing Corynebacterium glutamicum gRNA design Base deaminase N-acetylglucosamine
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2214030120300158
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