Finely tuned ionizable lipid nanoparticles for CRISPR/Cas9 ribonucleoprotein delivery and gene editing

Abstract Nonviral delivery of the CRISPR/Cas9 system provides great benefits for in vivo gene therapy due to the low risk of side effects. However, in vivo gene editing by delivering the Cas9 ribonucleoprotein (RNP) is challenging due to the poor delivery into target tissues and cells. Here, we intr...

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Hlavní autoři:	San Hae Im, Mincheol Jang, Ji-Ho Park, Hyun Jung Chung
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-04-01
Edice:	Journal of Nanobiotechnology
Témata:	CRISPR/Cas9 Lipid nanoparticles Ribonucleoprotein In vivo delivery
On-line přístup:	https://doi.org/10.1186/s12951-024-02427-2
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