SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma

Summary: Glioblastoma (GBM) relies on fatty acid metabolism for aggressive growth. This study identifies stearoyl-CoA desaturase-5 (SCD5), a brain-enriched isoform, as a critical driver of glioblastoma stem cell (GSC) maintenance and genomic stability. While SCD1’s role in GBM is well-established, o...

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Detalles Bibliográficos

Principais autores:	Hayk Mnatsakanyan, Alessandro Sammarco, Abigail Hewett, Rami Awwad, Elie Roumieh, Caline Pechdimaljian, Cagri Cakici, Caroline M. Spangler, Yana Azar, Richa Pradhan, Baolong Su, Kevin J. Williams, Steven J. Bensinger, Christian E. Badr
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-04-01
Series:	Cell Reports
Assuntos:	CP: cancer CP: metabolism
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124726003013
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