SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma

Summary: Glioblastoma (GBM) relies on fatty acid metabolism for aggressive growth. This study identifies stearoyl-CoA desaturase-5 (SCD5), a brain-enriched isoform, as a critical driver of glioblastoma stem cell (GSC) maintenance and genomic stability. While SCD1’s role in GBM is well-established, o...

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Үндсэн зохиолчид:	Hayk Mnatsakanyan, Alessandro Sammarco, Abigail Hewett, Rami Awwad, Elie Roumieh, Caline Pechdimaljian, Cagri Cakici, Caroline M. Spangler, Yana Azar, Richa Pradhan, Baolong Su, Kevin J. Williams, Steven J. Bensinger, Christian E. Badr
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2026-04-01
Цуврал:	Cell Reports
Нөхцлүүд:	CP: cancer CP: metabolism
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2211124726003013
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!