TBK1 mutation and its role in frontotemporal dementia and amyotrophic lateral sclerosis in Brazilian families

ABSTRACT. Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are progressive neurodegenerative diseases with unclear etiology. Mutations in the TBK1 gene are associated with an increased risk of both FTD and ALS, presenting a diverse phenotype that includes the behavioral variant...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Rachel Leirner Argelazi, Santhiago Calvelo Graça, Pedro Vilaça Thomazoni, Carolina Braga Moura, Ana Carolina Gomes, Matheus Kohama Kormanski, Sephora Sabrina Candido de Almeida, Yngrid Dieguez Ferreira, Diogo Haddad Santos
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2025-10-01
Schriftenreihe:	Dementia & Neuropsychologia
Schlagworte:	Frontotemporal Dementia Amyotrophic Lateral Sclerosis Mental Disorders Epidemiology Genetics
Online-Zugang:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100314&tlng=en
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