CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer’s disease

Abstract Background Early detection of amyloid-β (Aβ) pathology is critical for timely intervention in Alzheimer’s disease (AD). While Aβ positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers are accurate, their high cost and limited accessibility hinder routine use. We develop...

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Bibliografske podrobnosti

Principais autores:	Sohyun Yim, Seongbeom Park, Kyoung Yoon Lim, Heekyoung Kang, Daeun Shin, Hyemin Jang, Michael Weiner, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Sung Hoon Kang, Jihwan Yun, Minyoung Chun, Eunjoo Kim, Heejin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, Kichang Kwak, K-ROAD study
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-10-01
Serija:	Alzheimer’s Research & Therapy
Teme:	Alzheimer’s disease Two-stage diagnostic workflow Amyloid status Computed tomography Plasma p-tau217 Machine learning
Online dostop:	https://doi.org/10.1186/s13195-025-01870-z
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