Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci

Abstract The biological functions of extragenic enhancer RNAs and their impact on disease risk remain relatively underexplored. In this work, we develop in silico models of genetically regulated expression of enhancer RNAs across 49 cell and tissue types, characterizing their degree of genetic contr...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Michael J. Betti, Phillip Lin, Melinda C. Aldrich, Eric R. Gamazon
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2025-04-01
Σειρά:	Nature Communications
Διαθέσιμο Online:	https://doi.org/10.1038/s41467-025-58023-x
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