FOS drives podocyte injury and renal fibrosis in diabetic kidney disease via direct Smad3 binding

Abstract Introduction Epithelial-mesenchymal transition (EMT) plays a crucial role in diabetic kidney disease (DKD), particularly in the context of podocyte EMT. However, the regulatory networks controlling EMT activation in podocytes remain incompletely mapped. The FOS proto-oncogene (FOS) has emer...

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Detalhes bibliográficos

Principais autores:	Man Sun, Tianchi Yan, Wenjing Zhao, Zhifeng Cheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2026-04-01
coleção:	Cellular and Molecular Life Sciences
Assuntos:	Diabetic kidney disease FOS EMT Fibrosis TGF-β/Smad3
Acesso em linha:	https://doi.org/10.1007/s00018-026-06215-z
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