Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53(R175H) and mouse Trp53(R172H), that can be activ...
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| Główni autorzy: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2012-01-01
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| Seria: | PLoS ONE |
| Dostęp online: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071491/?tool=EBI |
| Etykiety: |
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