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Exploring ischemic stroke based on the ferroptosis perspective: ECH1 may serve as a new biomarker and therapeutic target

BackgroundIschemic stroke (IS), the leading stroke subtype (∼87%), arises from vascular occlusions, triggering brain necrosis through ischemia-reperfusion injury. Ferroptosis, an iron-driven cell death via Fe2+-mediated lipid peroxidation, is implicated in IS pathology. This study demonstrates that...

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Principais autores: Rendong Qu, Yiyan Zhang, Haojia Zhang, Ke Li, Boning Zhang, Hongxuan Tong, Tao Lu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-08-01
Serier:Frontiers in Neuroscience
Fag:
ischemic stroke
ferroptosis
peripheral blood
ECH1
tMCAO
Online adgang:https://www.frontiersin.org/articles/10.3389/fnins.2025.1622760/full
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