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Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show that the antioxidant enzyme peroxiredoxin 1 (P...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Eric Aeby, Wareed Ahmed, Sophie Redon, Viesturs Simanis, Joachim Lingner
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016-12-01
Schriftenreihe:Cell Reports
Schlagworte:
telomeres
telomerase
oxidative stress
peroxiredoxin 1
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S221112471631645X
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