SMAD4 mutation drives gut microbiome shifts toward tumor progression in colorectal cancer

Abstract Background Colorectal cancer (CRC) progression is driven by a series of sequential mutations in key driver genes; however, the factors underlying tumor progression and metastasis remain poorly understood. Mutations in TP53 and SMAD4, in particular, are associated with CRC progression. Altho...

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主要な著者:	Travis J. Gates, Dechen Wangmo, Kyra M. Boorsma Bergerud, Bridget M. Keel, Christopher Staley, Subbaya Subramanian
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer 2025-10-01
シリーズ:	Discover Oncology
主題:	Gut microbiome SMAD4 Driver gene mutations Colorectal cancer Metastasis
オンライン･アクセス:	https://doi.org/10.1007/s12672-025-02580-6
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