A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model

Abstract Background Combining radiotherapy with PD1 blockade has had impressive antitumor effects in preclinical models of metastatic lung cancer, although anti-PD1 resistance remains problematic. Here, we report results from a triple-combination therapy in which NBTXR3, a clinically approved nanopa...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Yun Hu, Sébastien Paris, Hampartsoum Barsoumian, Chike O. Abana, Kewen He, Duygu Sezen, Mark Wasley, Fatemeh Masrorpour, Dawei Chen, Liangpeng Yang, Joe D. Dunn, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez, James W. Welsh
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2021-12-01
Sarja:	Journal of Nanobiotechnology
Aiheet:	Nanoparticle Metastatic lung cancer Radioimmunotherapy Checkpoint blockade Immune memory NBTXR3
Linkit:	https://doi.org/10.1186/s12951-021-01163-1
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