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ERK5 and cell proliferation: nuclear localization is what matters

ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell proliferation in normal and cancer cells by mechani...

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Principais autores: Nestor Gomez, Tatiana Erazo, Jose M Lizcano
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016-09-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
Cell Proliferation
MAP Kinase Signaling System
Transcriptional Activation
Cancer
Erk5
nuclear translocation
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00105/full
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