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The radiosensitizing effects of a STAT3/HDAC dual-target inhibitor derived from isoalantolactone in solid tumor models

Abstract Multi-target combination therapy has emerged as a promising anti-cancer strategy. STAT3 and HDAC are key contributors to tumorigenesis and progression. We previously reported the design of a novel dual-target inhibitor of STAT3 and HDAC (named mhl-28), which was developed by employing a nat...

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Principais autores: Qi Wang, Haiyan Qiu, Rongfei Zhu, Rong Li, Jiahan Qiao, Chun Fu, Yaxin Tang, Aihua Shen, Junfang Yan, Denggao Zhao, Burong Hu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:BMC Cancer
Fag:
STAT3/HDAC
Isoalantolactone
Dual-target inhibitor
Radiosensitization
Antitumor
Online adgang:https://doi.org/10.1186/s12885-026-15816-7
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