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In Silico Targeting of Trypanothione Reductase and Glycerol-3-Phosphate Dehydrogenase in <i>Leishmania</i>

Leishmaniasis remains a neglected tropical disease with treatment limitations driven by toxicity, cost, and emerging resistance. Trypanothione reductase (TryR) and glycerol-3-phosphate dehydrogenase (GPDH) are essential <i>Leishmania</i> enzymes supporting redox homeostasis and energy/redox-linked m...

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Autore principale: Ali Alisaac
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-02-01
Serie:Microorganisms
Soggetti:
leishmaniasis
leishmania trypanothione reductase (TryR)
glycerol-3-phosphate dehydrogenase (GPDH)
dual inhibitors
redox homeostasis
energy metabolism
Accesso online:https://www.mdpi.com/2076-2607/14/2/407
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