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The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Abstract Background Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. Thereb...

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Autori principali: Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek, Wolfdieter Springer
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-04-01
Serie:Molecular Neurodegeneration
Soggetti:
Parkinson’s disease
PINK1
PARKIN
Ubiquitin
Mitophagy
Autophagy
Accesso online:http://link.springer.com/article/10.1186/s13024-017-0174-z
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