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N-terminal acetylation reduces synuclein pathology in models of Parkinson's disease

α-synuclein protein is a major constituent of pathological intracellular inclusions such as Lewy bodies found in brains of patients with Parkinson's disease and other synucleinopathies. Whereas α-synuclein phosphorylation has been much studied, comparatively less work has been devoted to other post-...

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Principais autores: Esther del Cid-Pellitero, Thomas Goiran, Zaid A.M. Al-Azzawi, Nathan C. Karpilovsky, Jace Jones-Tabah, Jonas J. Mayo, Frederique Larroquette, Wen Luo, Irina Shlaifer, Yogitha Thattikota, Andrew Bayne, Jean-Francois Trempe, Thomas M. Durcan, Edward A. Fon
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-09-01
coleção:Neurobiology of Disease
Assuntos:
N-terminal acetylation
Parkinson's disease
Alpha-synuclein
Phosphorylated Synuclein
Aggregation
Uptake
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996126002305
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