Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia

Tetracyclines inhibit matrix metalloproteinases (MMPs) and reduce infarction volume following cerebral ischemia. In this thesis an involvement of urokinase could be proven. Cerebral ischemia in rats was induced for 3 h followed by 24 h reperfusion (suture model). Each 6 animals received orally eithe...

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Главные авторы:	Dorothe Burggraf, Andreas Trinkl, Martin Dichgans, Gerhard F. Hamann
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2007-03-01
Серии:	Neurobiology of Disease
Предметы:	Cerebral ischemia Doxycycline MMPs Plasminogen activator Rat TIMP
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S0969996106002853
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