Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the nucleus accumbens and prefrontal cortex. As all...

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Autores principales:	Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gómez-A, Todd K. O’Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-01-01
Colección:	Frontiers in Pharmacology
Materias:	neurosteroid allopregnanolone progesterone voltammetry dopamine nucleus accumbens
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2020.608887/full
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