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Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the nucleus accumbens and prefrontal cortex. As all...

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Hoofdauteurs: Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gómez-A, Todd K. O’Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021-01-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
neurosteroid
allopregnanolone
progesterone
voltammetry
dopamine
nucleus accumbens
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2020.608887/full
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