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Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

Abstract In lung disease, persistence of KRT8-expressing aberrant basaloid cells in the alveolar epithelium is associated with impaired tissue regeneration and pathological tissue remodeling. We analyzed single cell RNA sequencing datasets of human interstitial lung disease and found the profibrotic...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Benjamin Ng, Kevin Y. Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim, Fathima F. Kuthubudeen, Yu-Ning Liu, An An Hii, Benjamin L. George, Anissa A. Widjaja, Enrico Petretto, Stuart A. Cook
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2024-10-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-024-52810-8
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