Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated. Here we dissect IL11 signaling in fibroblasts an...

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Bibliografski detalji

Glavni autori:	Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G. Shekeran, Benjamin L. George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A. Cook
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2021-09-01
Serija:	Frontiers in Molecular Biosciences
Teme:	interleukin-11 signaling fibrosis fibroblasts nintedanib IL11
Online pristup:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.740650/full
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