Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function

Targeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors. Blocking the immune checkpoint PD-1 binding to its ligands PD-L1 and PD-L2 prevents downstream signaling and en...

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Hlavní autoři:	Luke Yi Hao, Shalom Lerrer, Matthieu Paiola, Emily K. Moore, Yevgeniya Gartshteyn, Ruijiang Song, Michael Goeckeritz, Matilda J. Black, Shoiab Bukhari, Xizi Hu, Adam Mor
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-09-01
Edice:	Molecular Therapy: Oncology
Témata:	MT: Regular Issue immune synapse t cells monoclonal antibodies cancer immunotherapy immune checkpoints
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S295032992400081X
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