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Structural basis of tetanus toxin neutralization by native human monoclonal antibodies

Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT immunoglobulin. TT0170 binds fragment B, and TT00...

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Principais autores: Yueming Wang, Changwen Wu, Jinfang Yu, Shujian Lin, Tong Liu, Lipeng Zan, Nan Li, Po Hong, Xiaoli Wang, Zhenxing Jia, Jason Li, Yao Wang, Ming Zhang, Xiaohui Yuan, Chengming Li, Wenwen Xu, Weihong Zheng, Xinquan Wang, Hua-Xin Liao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-05-01
Colecção:Cell Reports
Assuntos:
tetanus
tetanus toxin
toxin neutralization
native human monoclonal antibody
immunoglobulin
ganglioside
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124721004010
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