Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the main components in the Rhizoma of Paris polyphyllin, displays a selective inhibitory effect on various tumor cells. Here...

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Autori principali:	Qiong Wang, Xin Zhou, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Yongjun Wang, Hongyan Wang, Qianqian Liang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2018-09-01
Serie:	Frontiers in Immunology
Soggetti:	polyphyllin I collagen-induced arthritis primary macrophages NF-κB inflammation
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02091/full
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