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Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics

Glioblastoma (GBM) is the most aggressive malignant primary brain tumour with a median overall survival of 15 months. To treat GBM, patients currently undergo a surgical resection followed by exposure to radiotherapy and concurrent and adjuvant temozolomide (TMZ) chemotherapy. However, this protocol...

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Uloženo v:
Hlavní autoři: Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy, Marc Sturrock
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2020-07-01
Edice:Royal Society Open Science
Témata:
glioblastoma
drug resistance
o-6-methylguanine-dna methyltransferase
stochastic modelling
multi-scale model
phenotypic selection
On-line přístup:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191243
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