Single cell transcriptomics reveals recent CD8T cell receptor signaling in patients with coronary artery disease

Coronary artery disease (CAD) is a major cause of death worldwide. The role of CD8+ T cells in CAD is unknown. Recent studies suggest a breakdown of tolerance in atherosclerosis, resulting in active T cell receptor (TCR) engagement with self-antigens. We hypothesized that TCR engagement would leave...

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Autori principali:	Shahad Iqneibi, Ryosuke Saigusa, Amir Khan, Mohammad Oliaeimotlagh, Sujit Silas Armstrong Suthahar, Sunil Kumar, Ahmad Alimadadi, Christopher P. Durant, Yanal Ghosheh, Coleen A. McNamara, Catherine C. Hedrick, Klaus Ley
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-09-01
Serie:	Frontiers in Immunology
Soggetti:	atherosclerosis CAD tolerance CD8 T cells scRNA-seq CITE-Seq
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239148/full
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