Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from <i>Salmonella</i>

<i>Salmonella</i> is an important genus of Gram-negative pathogens, treatment of which has become problematic due to increases in antimicrobial resistance. This is partly attributable to the overexpression of tripartite efflux pumps, particularly the constitutively expressed AcrAB-TolC. Despite its...

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Bibliografische Detailangaben

Hauptverfasser:	Rachel M. Johnson, Chiara Fais, Mayuriben Parmar, Harish Cheruvara, Robert L. Marshall, Sophie J. Hesketh, Matthew C. Feasey, Paolo Ruggerone, Attilio V. Vargiu, Vincent L. G. Postis, Stephen P. Muench, Vassiliy N. Bavro
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-06-01
Schriftenreihe:	Microorganisms
Schlagworte:	<i>Salmonella</i> multidrug efflux pump membrane proteins multidrug resistance AcrB cryo-EM
Online-Zugang:	https://www.mdpi.com/2076-2607/8/6/943
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